KMID : 1211620130080040539
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Journal of the Korean Society of Physical Medicine 2013 Volume.8 No. 4 p.539 ~ p.547
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The Effects of Exercise of Diverse Intensities on the Expression of TNF-¥á in the Spinal Cord in Osteoarthritic Rats
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¹Ú¼öÁø:Park Soo-Jin
ÀúÀÚ¾øÀ½:No authors listed
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Abstract
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PURPOSE : This study examined the effects of exercise of diverse intensities on the expression of TNF-¥á(tumor necrosis factor-¥á) in the spinal cord in osteoarthritic rats.
METHODS : Over a period of four weeks, the authors applied treadmill exercise programs of diverse intensities to Sprague-Dawley rats, to which intra-articular injection of monosodium iodoacetate(MIA, 3§·/50§¡, diluted in saline) was applied to the right knee joint to induce osteoarthritis. The four-week exercise program was not carried out with the control group(CG, n=10). Exercise programs of applicable intensities were applied to the low-intensity exercise group(LEG, n=10), moderate-intensity exercise group (MEG, n=10), and high-intensity exercise group(HEG, n=10) over the four weeks. bservations were made of expression of TNF-¥á in the spinal cord in osteoarthritic rats using western blot analysis.
RESULT : there were significant differences(p<.05) in the comparison of expression of TNF-¥á between the four groups involved. The expression of TNF-¥á in the spinal cord, the LEG and HEG had more elevated expression significantly than he CG(p<.05). But the MEG had reduced expression significantly than the CG(p<.05).
CONCLUSION : These study results suggest that moderate-intensity exercise is effective in inhibition TNF-¥á in the spinal cord. They also indicate that in prescribing exercise to treat osteoarthritic patients, exercise of moderate intensity is most suitable to patients¡¯ chronic pain, rather than low or high intensity.
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KEYWORD
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Osteoarthritis, Chronic pain, TNF-¥á, Exercise intensity
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